Hello, there is more bad news for those suffering with obesity and a dire need for natural weight loss to be sought out by such people. An article running on medicalnewstoday confirms this bad news.
According to the article: “Researchers at the University of Toronto, Faculty of Medicine, Toronto, Canada, have discovered that adiponectin, a protein secreted from adipocytes, is a metabolic link that can explain, in part, the known positive relationship between obesity and both bone mineral density and reduced susceptibility to fractures. This study appears in the December issue of Experimental Biology and Medicine. Circulating adiponectin levels are significantly lower in obese humans and rodent models than in lean controls. It is known that excess body weight and elevated body mass index are strongly correlated with high bone mineral density, and that weight loss is associated with loss of bone mineral density and increased risk of fractures. However, the mechanism for this relationship is unclear.
The research team, Dr. Michael C. Archer, Earle W. McHenry Professor and Chair, Dr. Wendy E. Ward, Associate Professor, Dr. Kafi Ealey, Postdoctoral Fellow and predoctoral student Jovana Kaludjerovic, in the Department of Nutritional Sciences, investigated whether adiponectin modulates bone development using transgenic mice that overexpress this protein. These mice were initially developed by Dr. P. Scherer’s research group at Albert Einstein College of Medicine, N.Y. Bone mineral density and biomechanical strength properties, surrogate measures of fracture risk at multiple skeletal sites, were the outcomes used to assess bone development. Female mice overexpressing adiponectin had weaker vertebra at 8 weeks of age than control mice and this delay in bone development persisted through to the end of the study period, representing early adulthood. The weaker vertebra model compression fractures of the lumbar spine in humans, among the most common type of fragility fracture associated with low bone mass and osteoporosis. The strength of the femur neck, representing the hip, was also weaker in both females and males overexpressing adiponectin. Serum adiponectin levels were inversely correlated with femur bone mineral content, further emphasizing that a high level of adiponectin impedes bone development at not only the lumbar spine but also the hip. Whether or not the delay in bone development resolves in later life or is sustained and leads to an increased risk of fragility fracture, particularly during aging when bone loss rapidly occurs due to declining levels of sex steroids, requires further investigation.”
Thus it is clear that natural weight loss techniques need to be improved.
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